This allowed the scientists to produce a precise visualization of the tegument proteins, which look like five-pointed stars and line the outside of the virus capsid in a regular, or highly ordered, lattice.
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The study was supported in part by grants from the National Institutes of Health and the China Scholarship Council. Instruments at UCLA s Electron Imaging Center for NanoMachines that were used to obtain images for the published structure are supported.
Weve known that HSV-1 can hide inside the nucleus of the nerve cell and establish life-long latent infection inside most of us, said Xinghong Dai, a UCLA researcher and the studys first author.
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This is the first time weve seen how those cellular transport vehicles could bind to their cargo, the HSV-1 capsid the protein shell of the virus. The studys senior author is Z.
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